MAY 2024 – Identification of potent pan-ephrin receptor kinase inhibitors using DECL technology
In this report, DNA-encoded chemical library screenings were used to develop potent, selective and nonhormonal inhibitors of the EPH receptor kinase family. EPH receptors (EPHs), the largest family of tyrosine kinases, phosphorylate downstream substrates upon binding of ephrin cell surface–associated ligands. EPHA2 and EPHA4 expressions are increased in endometriotic lesions. Therefore, chemical inhibition of EPHA2/4 receptors could have … Read more