DECLTech Consulting

Dr. Luca Mannocci

Born in Pisa on 7th September 1979, I studied Chemistry at the University of Pisa with a focus on the synthesis and characterization of pharmaceutically relevant naturally occurring compounds. In 2008, I earned my doctorate in Chemistry under the supervision of Professor Dario Neri in the Institute of of Pharmaceutical Sciences at the ETH Hönggerberg (Zurich, Switzerland), with a dissertation on the first implementation of high-throughput sequencing for the decoding of various DNA-encoded chemical library formats.

In 2009, I joined Philochem AG where as Head of DNA-Encoded Chemistry I led a drug discovery unit dedicated to the design and development of DNA-encoded chemical libraries for drug discovery applications. I am author of several publications in peer-reviewed journals on DECL-technology, co-author of the Wikipedia “DNA-encoded chemical library” webpage, start-up mentor and co-organizer of the first two International Symposium on DNA-encoded chemical libraries.

In addition to over 10 years’ experience in DNA-Encoded Chemical library field, I have an extensive background in isolation, characterization and optimization of low molecular weight hit compounds, as well as in chemical modification and conjugation of biomacromolecules, like antibody, antibody fragments and protein antigens.

DECLTech

DECLTech consulting was founded in 2013 with the aim to provide pharmaceutical, healthcare and biotech stakeholders with the right scientific expertise and technical guidance to successfully implement DECL technologies in drug/ligand discovery programs in order to maximise DECL potentials with tailored solutions.

Contact us for:

  • DECL Technology consulting 
  • DECL tech-transfer and implementation guidance
  • DECL Technology tailored solutions
  • Project Management support
  • Collaboration, services and partnership mediator
  • DECL fund rising & grant application review
  • Project risk and opportunities assessment

Publications & Patents

Mannocci L, (2014) Introductory Comment 3 “A new solution for an old problem: Finding a needle in the haystack“; A Handbook for DNA-Encoded Chemistry: Theory and Applications for Exploring Chemical Space and Drug Discovery
Mannocci L, (2013) Chapter 11 “DNA-Encoded Chemical Libraries“; Part II Chemical Libraries and Diversity-Oriented Synthesis; Diversity-Oriented Synthesis: Basics and Applications in Organic Synthesis, Drug Discovery, and Chemical Biology
  • Leimbacher M, Mannocci, L, et al. (2012) Discovery of small-molecule Interleukin-2 inhibitors from a DNA-encoded chemical library. Chem. Eur. J.,18, 7729-7737.
  • Mannocci L, et al. (2011), 20 years of DNA-encoded chemical libraries. Chem. Commun., 47, 12747-12753.
  • Mannocci L, et al. (2010) Isolation of potent and specific trypsin inhibitors from a DNA-encoded chemical library. Bioconjug Chem 21(10):1836-1841.
  • Melkko S, Mannocci L, et al. (2010) Isolation of a small-molecule inhibitor of the antiapoptotic protein Bcl-xL from a DNA-encoded chemical library. (Translated from eng) Chem.Med.Chem. 5(4):584-590.
  • Buller F, Steiner M, Scheuermann J, Mannocci L, et al. (2010) High-throughput sequencing for the identification of binding molecules from DNA-encoded chemical libraries. Bioorg Med Chem Lett 20(14):4188-4192.
  • Buller F, Mannocci L, Scheuermann J, & Neri D (2010) Drug discovery with DNA-encoded chemical libraries. Bioconjug Chem 21(9):1571-1580.
  • Mannocci L., Neri D., Melkko S., (2009) “DNA-Encoded Chemical Libraries”. SCREENING – Trends in Drug Discovery, 10:16-18
  • Scheuermann J, Dumelin CE, Melkko S, Mannocci L, et al. (2008) DNA-encoded chemical libraries for the discovery of MMP-3 inhibitors. Bioconjug Chem 19(3):778-785.
  • Mannocci L, et al. (2008) High-throughput sequencing allows the identification of binding molecules isolated from DNA-encoded chemical libraries. Proc Natl Acad Sci U S A 105(46):17670-17675.
  • Dumelin CE, Trussel S, Buller, F., Mannocci L, et al. (2008) A portable albumin binder from a DNA-encoded chemical library. Angew Chem Int Ed Engl 47(17):3196-3201.
  • Buller F, Mannocci L, et al. (2008) Design and synthesis of a novel DNA-encoded chemical library using Diels-Alder cycloadditions. Bioorg Med Chem Lett 18(22):5926-5931.
  • Carpita A, Mannocci L, Rossi R (2005) Silver(I)-catalysed protiodesilylation of 1-(trimethylsilyl)-1-alkynes. (Translated from English) Eur J Org Chem (9):1859-1864.
  • Bellina F, Carpita A, Mannocci L, Rossi R (2004) First total synthesis of naturally occurring (-)-nitidon and its enantiomer. Eur J Org Chem (12):2610-2619.
  • W. Lin, Y. Zhang, R. Wieduwild, A. Thomas, M. Thompson, L. Mannocci “Regenerable Biosensor Chips” (PCT register number: PCT/EP2014/064097)
  • Mannocci L., Casi G., Neri D., Method of Generating an Encoded Chemical Library. US Application 2012 No: 61/579973
  • Mannocci L., Melkko S., Neri D., DNA-encoded chemical libraries. US Patent Application 2008 No 61/008,249.